Predicting the effect of climate change on the distribution of valuable and endangered plant species is essential for their conservation and management. In this study, the MaxEnt model and 10 environmental variables were used to predict the current and future distribution of E. amoenum and E. italicum in response to climate change. Also, to predict the effect of climate change in the future (the 2050s and 2070s), two climate scenarios of RCP 2.6 and RCP8.5 were used under the CCSM4 general circulation model. Evaluating the accuracy of the models based on the AUC index indicates their excellent performance (<0.9). Resutls  of this study reveal that the most important variables affecting the distribution of E. amoenum species are slope (38.8%), annual temperature range (11.5%), and precipitation in the driest season (31.9%) are. Also, the solar radiation (37.6%), slope (36.4%), and the average temperature of the coldest season (11.5%) are the most important environmental factors affecting the distribution of E. italicum. In addition, the results show that the distribution of the studied species will decrease in response to climate change and under RCP2.6 and RCP8.5 in the 2050s and 2070s. Therefore, the results of this study emphasize the need to develop  conservation strategies to prevent the extinction of these species.