This study aimed the investigating the structure of energy production and the global warming potential of wheat production in Mehran and Dehloran regions. Information about the consumption of inputs and outputs was collected through questionnaires and interviews with local farmers. The results of the research showed that the total energy consumptions in these areas were equal to 6715.3and 68988.4 MJ/ha, and the energy outputs were calculated as 81820 and 94390 MJ/ha, respectively. Economic analysis showed that the profit-to-cost ratios in Mehran and Dehloran regions were equal to 1.42 and 1.58, and the economic productivity of productions were 3.17 and 3.52 kg /Rial, respectively. Based on the Cobb-Douglas function, the coefficients of determination (R2) in Mehran and Dehloran regions were 0.93 and 0.96 respectively. The amount of total emissions of carbon dioxide, nitrogen oxide and methane from wheat cultivation in Mehran was 1328.73, 8228.67 and 33.35 kg/ha, respectively, and in Dehloran was equal to 1431.26, 8503.67 and 36.08 kg/ha, respectively. The global warming potential value of production in Mehran region was at about 9590.75 and in Dehloran region equaled to 9971.01 kg equivalent of carbon dioxide per hectare.